FEV1 Is a Better Predictor of Mortality than FVC: The PLATINO Cohort Study

Menezes, AMB; Perez-Padilla, R; Wehrmeister, FC; Lopez-Varela, MV; Muino, A; Valdivia G.; Lisboa C.; Jardim, JRB; de Oca, MM; Talamo, C; Bielemann, R; Gazzotti, M; Laurenti, R; Celli, B; Victoria, CG

Abstract

Objective: To determine whether the presence of chronic obstructive lung disease (COPD) and reduction of lung function parameters were predictors of mortality in a cohort. Materials/Patients and Methods: Population based cohorts were followed in Montevideo, Santiago and Sao Paulo during 5, 6 and 9 years, respectively. Outcomes included all-cause, cardiovascular, respiratory and cancer mortality; exposures were COPD, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Cox regression was used for analyses. Sensitivity, specificity, positive and negative predictive values, receiver operator characteristics curves and Youden's index were calculated. Results: Main causes of death were cardiovascular, respiratory and cancer. Baseline COPD was associated with overall mortality (HR = 1.43 for FEV1/FVC

Más información

Título según WOS: FEV1 Is a Better Predictor of Mortality than FVC: The PLATINO Cohort Study
Título según SCOPUS: FEV1 is a better predictor of mortality than FVC: The platino cohort study
Título de la Revista: PLOS ONE
Volumen: 9
Número: 10
Editorial: PUBLIC LIBRARY SCIENCE
Fecha de publicación: 2014
Idioma: English
DOI:

10.1371/journal.pone.0109732

Notas: ISI, SCOPUS