Tumor cell lysates as immunogenic sources for cancer vaccine design

Gonzalez, FE; gleisner a; Falcon-Beas, F; Osorio, F; López MN; SALAZAR ONFRAY F

Keywords: gm-csf, calreticulin, dendritic cells, antigens, toll-like receptors, heat shock proteins, am, ctls, damps, damage-associated molecular patterns, dcs, HMGB1, cancer immunotherapy, DTH

Abstract

Autologous dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are a promising immunological tool for cancer therapy. These stimulate the antitumor response and immunological memory generation. Nevertheless, many patients remain refractory to DC approaches. Antigen (Ag) delivery to DCs is relevant to vaccine success, and antigen peptides, tumor-associated proteins, tumor cells, autologous tumor lysates, and tumor-derived mRNA have been tested as Ag sources. Recently, DCs loaded with allogeneic tumor cell lysates were used to induce a potent immunological response. This strategy provides a reproducible pool of almost all potential Ags suitable for patient use, independent of MHC haplotypes or autologous tumor tissue availability. However, optimizing autologous tumor cell lysate preparation is crucial to enhancing efficacy. This review considers the role of cancer cell-derived lysates as a relevant source of antigens and as an activating factor for ex vivo therapeutic DCs capable of responding to neoplastic cells. These promising therapies are associated with the prolonged survival of advanced cancer patients.

Más información

Título según WOS: Tumor cell lysates as immunogenic sources for cancer vaccine design
Título según SCOPUS: Tumor cell lysates as immunogenic sources for cancer vaccine design
Título de la Revista: HUMAN VACCINES & IMMUNOTHERAPEUTICS
Volumen: 10
Número: 11
Editorial: TAYLOR & FRANCIS INC
Fecha de publicación: 2014
Página de inicio: 3261
Página final: 3269
Idioma: English
DOI:

10.4161/21645515.2014.982996

Notas: ISI, SCOPUS