A retinoic acid-dependent checkpoint in the development of CD4(+) T cell-mediated immunity

Pino-Lagos, K; Guo, YX; BROWN C.; Alexander, MP; Elgueta R.; Bennett, KA; De Vries, V; Nowak, E.; Blomhoff, R; Sockanathan, S; Chandraratna, RA; Dmitrovsky, E; Noelle, RJ

Abstract

It is known that vitamin A and its metabolite, retinoic acid (RA), are essential for host defense. However, the mechanisms for how RA controls inflammation are incompletely understood. The findings presented in this study show that RA signaling occurs concurrent with the development of inflammation. In models of vaccination and allogeneic graft rejection, whole body imaging reveals that RA signaling is temporally and spatially restricted to the site of inflammation. Conditional ablation of RA signaling in T cells significantly interferes with CD4(+) T cell effector function, migration, and polarity. These findings provide a new perspective of the role of RA as a mediator directly controlling CD4(+) T cell differentiation and immunity.

Más información

Título según WOS: A retinoic acid-dependent checkpoint in the development of CD4(+) T cell-mediated immunity
Título de la Revista: JOURNAL OF EXPERIMENTAL MEDICINE
Volumen: 208
Número: 9
Editorial: ROCKEFELLER UNIV PRESS
Fecha de publicación: 2011
Página de inicio: 1767
Página final: 1775
Idioma: English
DOI:

10.1084/jem.20102358

Notas: ISI