Article
Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus  (2015)

Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus

Mario Gonzalez-Gronow; Miguel Cuchacovich; Rina Franco; Stephanie Cuchacovich; Angel Blanco; Rodrigo Sandoval; Cristian Farías Gómez; Javier A. Valenzuela; Rupa Ray; Salvatore V. Pizzo

Keywords: Autism Autoimmunity Myelin basic protein Protease antibodies Synaptic plasticity Rat hippocampi

Abstract

Autoantibodies from autistic spectrum disorder (ASD) patients react with multiple proteins expressed in the brain. One such autoantibody targets myelin basic protein (MBP). ASD patients have autoantibodies to MBP of both the IgG and IgA classes in high titers, but no autoantibodies of the IgM class. IgA autoantibodies act as serine proteinases and degrade MBP in vitro. They also induce a decrease in long-term potentiation in the hippocampi of rats either perfused with or previously inoculated with this IgA. Because this class of autoantibody causes myelin sheath destruction in multiple sclerosis (MS), we hypothesized a similar pathological role for them in ASD. © 2015 Elsevier B.V. All rights reserved

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Título de la Revista: Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus
Volumen: 287
Fecha de publicación: 2015
Página de inicio: 1
Página final: 8
Idioma: English
Notas: Elsevier. Journal of Neuroimmunology