Trypanosoma cruzi: H2 complex and genetic background influence on the humoral immune response against epimastigotes

Aguillón JC; Hermosilla T.; Molina, MC; Morello A.; Repetto Y; Orn, A; Ferreira A.

Abstract

Using A.SW, A.CA, B10.S and B10.M congenic mouse strains, we measured the IgG specific humoral immune responses against sonicated and live Trypanosoma cruzi epimastigotes. Genes located in the A background (A.SW and A.CA strains) mediate higher IgG responses against the parasite antigenic complexes than those located in the B background (strains B10.S and B10.M), regardless of the H2 haplotypes. Thus, non H2 genetic elements seem to be more important in determining differences in the total IgG immune response against T. cruzi. Whether a detectable H2 effect, in favor of the H2(S) haplotype, occurred in the A or B background, was contingent on the immunisation protocol used. Thus, the H2S haplotype mediates a higher IG response in the A background, if immunised with live epimastigotes, and in the B background against sonicated epimastigotes. Most likely this represents a complex sequence of events, controlled by non-MHC genes, involving antigen handling and processing and depending on the physical form of antigen delivery. (C) 2000 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

Más información

Título según WOS: Trypanosoma cruzi: H2 complex and genetic background influence on the humoral immune response against epimastigotes
Título según SCOPUS: Trypanosoma cruzi: H2 complex and genetic background influence on the humoral immune response against epimastigotes
Título de la Revista: INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volumen: 30
Número: 9
Editorial: ELSEVIER SCI LTD
Fecha de publicación: 2000
Página de inicio: 981
Página final: 984
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0020751900000783
DOI:

10.1016/S0020-7519(00)00078-3

Notas: ISI, SCOPUS