Fc gamma RI (CD64): An identity card for intestinal macrophages

De Calisto, Jaime; Villablanca, Eduardo J.; Mora, J. Rodrigo

Abstract

Macrophages are becoming increasingly recognized as key cellular players in intestinal immune homeostasis. However, differentiating between macrophages and dendritic cells (DCs) is often difficult, and finding a specific phenotypic signature for intestinal macrophage identification has remained elusive. In this issue of the European Journal of Immunology, Tamoutounour et al. [Eur. J. Immunol. 2012. 42: 3150-3166] identify CD64 as a specific macrophage marker that can be used to discriminate DCs from macrophages in the murine small and large intestine, under both steady-state and inflammatory conditions. The authors also propose a sequential monocyte-waterfall model for intestinal macrophage differentiation, with implications for immune tolerance and inflammation at the gut mucosal interface. This Commentary will discuss the advantages and potential limitations of CD64 as a marker for intestinal macrophages.

Más información

Título según WOS: ID WOS:000312547800009 Not found in local WOS DB
Título de la Revista: EUROPEAN JOURNAL OF IMMUNOLOGY
Volumen: 42
Número: 12
Editorial: Wiley
Fecha de publicación: 2012
Página de inicio: 3136
Página final: 3140
DOI:

10.1002/eji.201243061

Notas: ISI