Identification of a 170-kDa protein over-expressed in lung cancers

Pincheira, R; Chen, Q; Zhang, JT

Abstract

Lung cancer is the leading cause for cancer death in both male and female populations. Although many molecular markers for lung cancer have been developed and useful for early detection of lung cancer, their function remains unknown. In this paper, we report our findings that a 170-kDa protein (p170) is over-expressed in ail types of human lung cancers compared with normal tissues and it is identified as a subunit of translation initiation factor elF3 by cDNA cloning, Translation initiation factors are a family of proteins that promote the initiation step of protein synthesis and are regulators of cell growth at the translational level. Further studies showed that p170 mRNA is ubiquitously expressed with higher levels in adult proliferating tissues (e.g. bone marrow) and tissues during development (e.g. fetal tissues), This study suggests that p170 and elF3 may be important factors for cell growth, development, and tumorigenesis. (C) 2001 Cancer Research Campaign.

Más información

Título según WOS: ID WOS:000169414900016 Not found in local WOS DB
Título de la Revista: BRITISH JOURNAL OF CANCER
Volumen: 84
Número: 11
Editorial: Nature Publishing Group
Fecha de publicación: 2001
Página de inicio: 1520
Página final: 1527
DOI:

10.1054/bjoc.2001.1828

Notas: ISI