Abstract

Nerve growth factor (NGF) regulates the functions of neurons by binding the p75 neurotrophin receptor (p75NTR) and TrkA receptors. It is shown here that it has been found that the Sal12 transcription factor forms a complex with p75NTR. NGF dissociates Sal12 from p75NTR and also activates TrkA, which promotes translocation of Sal12 into the nucleus. Nuclear Sal12 activates target genes that modulate the growth and development of neurons. Thus, one way that p75NTR and TrkA can modulate the functions of neurons is by regulating the localization and actions of Sal12.