Bioactive phenolic derivatives from Acaena splendens methanol extract

Backhouse, N; Delporte C.; Negrete, R; San Feliciano, SA; Lopez-Perez, JL

Abstract

Acaena splendens H. et A. has been used in Chilean folk medicine for the treatment of fever and inflammation. A description of the in vivo reduction of bacterial pyrogen-induced fever in rabbits and carrageenan-induced paw oedema in guinea pigs is presented. The methanol extract named ME-1, obtained after succesive extractions with petroleum ether and dichloromethane, showed a strong antipyretic action (45.7% of effect), though the antiinflammatory activity was only observed after submitting this extract to column fractionation, giving a crude mixture of flavonoids named C4 with both activities (55.7% and 98.9% of antiinflammatory and antipyretic effect respectively at a dose of 600 mg/kg). The bioassay-guided fractionation by column chromatography afforded the active fraction, which contained (-,-)-epicatechin, tiliroside, 7-O-acetyl-3-O-?-D-glucosyl-kaempferol and 7-?-D-glucosyloxy-5-hydroxy-chromone. Copyright © 2002 John Wiley & Sons, Ltd.

Más información

Título según WOS: Bioactive phenolic derivatives from Acaena splendens methanol extract
Título según SCOPUS: Bioactive phenolic derivatives from Acaena splendens methanol extract
Título de la Revista: PHYTOTHERAPY RESEARCH
Volumen: 16
Número: 6
Editorial: Wiley
Fecha de publicación: 2002
Página de inicio: 562
Página final: 566
Idioma: English
URL: http://doi.wiley.com/10.1002/ptr.997
DOI:

10.1002/ptr.997

Notas: ISI, SCOPUS