Anxiolytic-, antidepressant- and anticonvulsant-like effects of the alkaloid montanine isolated from Hippeastrum vittatum

Schurmann da Silva, Ana Flavia; Paulo de Andrade, Jean; M. Bevilaqua, Lia R.; Maria de Souza, Mdrcia; Izquierdo, Ivan; Henriques, Amlia Teresinha; Silveira Zuanazzi, Jose Angelo

Abstract

Compounds isolated from different members of the Amaryllidaceae family are becoming relevant options for the treatment of neurological disorders and neurodegenerative diseases. In particular, species of the Hippeastrum genus are important source of alkaloids with a wide profile of putative therapeutical applications. Here, we report on the behavioral and pharmaco-toxicological characterization of montanine, an isoquinoline alkaloid isolated from Hippeastrum vittatum, an ornamental plant found throughout the world. In mice, montanine showed a LD50 of 64.7 mg/kg and 67.6 mg/kg for male and female, respectively. When given i.p., montanine dose-dependently decreased sodium pentobarbital-induced sleep, protected against pentylenetetrazole-provoked convulsions, increased the number of entries and the time spent in the open arms of an elevated plus maze and augmented the time spent struggling during a forced swimming test. When given immediately after inhibitory avoidance training, montanine did not affect avoidance memory retention in rats. Our results suggest that montanine, as other alkaloids isolated from Amaryllidaceae species, has psychopharmacological activities including anxiolytic, antidepressive and anticonvulsive effects. (c) 2006 Elsevier Inc. All rights reserved.

Más información

Título según WOS: ID WOS:000242636000019 Not found in local WOS DB
Título de la Revista: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volumen: 85
Número: 1
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2006
Página de inicio: 148
Página final: 154
DOI:

10.1016/j.pbb.2006.07.027

Notas: ISI