Metabolic control by dehydroascorbic acid: Questions and controversies in cancer cells

Ferrada, Luciano; Salazar, Katterine; Nualart, Francisco

Abstract

For a long time, the effect of vitamin C on cancer cells has been a controversial concept. From Linus Pauling's studies in 1976, it was proposed that ascorbic acid (AA) could selectively kill tumor cells. However, further research suggested that vitamin C has no effect on tumor survival. In the last decade, new and emerging functions for vitamin C have been discovered using the reduced form, AA, and the oxidized form, dehydroascorbic acid (DHA), independently. In this review, we summarized the latest findings related to the effects of DHA on the survival and metabolism of tumor cells. At the same time, we put special emphasis on the bystander effect and the recycling capacity of vitamin C in various cellular models, and how these concepts can affect the experimentation with vitamin C and its therapeutic application in the treatment against cancer.

Más información

Título según WOS: Metabolic control by dehydroascorbic acid: Questions and controversies in cancer cells
Título según SCOPUS: Metabolic control by dehydroascorbic acid: Questions and controversies in cancer cells
Título de la Revista: JOURNAL OF CELLULAR PHYSIOLOGY
Volumen: 234
Número: 11
Editorial: WILEY-BLACKWELL
Fecha de publicación: 2019
Página de inicio: 19331
Página final: 19338
Idioma: English
DOI:

10.1002/jcp.28637

Notas: ISI, SCOPUS