On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier

Dutzan, Nicolas; Abusleme, Loreto; Bridgeman, Hayley; Greenwell-Wild, Teresa; Zangerle-Murray, Tamsin; Fife, Mark E.; Bouladoux, Nicolas; Linley, Holly; Brenchley, Laurie; Wemyss, Kelly; Calderon, Gloria; Hong, Bo-Young; Break, Timothy J.; Bowdish, Dawn M. E.; Lionakis, Michail S.; et. al.

Abstract

Immuno-surveillance networks operating at barrier sites are tuned by local tissue cues to ensure effective immunity. Site-specific commensal bacteria provide key signals ensuring host defense in the skin and gut. However, how the oral microbiome and tissue-specific signals balance immunity and regulation at the gingiva, a key oral barrier, remains minimally explored. In contrast to the skin and gut, we demonstrate that gingiva-resident T helper 17 (Th17) cells developed via a commensal colonization- independent mechanism. Accumulation of Th17 cells at the gingiva was driven in response to the physiological barrier damage that occurs during mastication. Physiological mechanical damage, via induction of interleukin 6 (IL-6) from epithelial cells, tailored effector T cell function, promoting increases in gingival Th17 cell numbers. These data highlight that diverse tissue-specific mechanisms govern education of Th17 cell responses and demonstrate that mechanical damage helps define the immune tone of this important oral barrier.

Más información

Título según WOS: ID WOS:000392918300016 Not found in local WOS DB
Título de la Revista: IMMUNITY
Volumen: 46
Número: 1
Editorial: Cell Press
Fecha de publicación: 2017
Página de inicio: 133
Página final: 147
DOI:

10.1016/j.immuni.2016.12.010

Notas: ISI