Hypothyroidism affects D2 receptor-mediated breathing without altering D2 receptor expression

Schlenker, Evelyn H.; del Rio, Rodrigo; Schultz, Harold D.

Abstract

Bromocriptine depressed ventilation in air and D2 receptor expression in the nucleus tractus solitaries (NTS) in male hypothyroid hamsters. Here we postulated that in age-matched hypothyroid female hamsters, the pattern of D2 receptor modulation of breathing and D2 receptor expression would differ from those reported in hypothyroid males. In females hypothyroidism did not affect D2 receptor protein levels in the NTS, carotid bodies or striatum. Bromocriptine, but not carmoxirole (a peripheral D2 receptor agonist), increased oxygen consumption and body temperature in awake air-exposed hypothyroid female hamsters and stimulated their ventilation before and following exposure to hypoxia. Carmoxirole depressed frequency of breathing in euthyroid hamsters prior to, during and following hypoxia exposures and stimulated it in the hypothyroid hamsters following hypoxia. Although hypothyroidism did not affect expression of D2 receptors, it influenced central D2 modulation of breathing in a disparate manner relative to euthyroid hamsters. (C) 2014 Elsevier B.V. All rights reserved.

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Título según WOS: ID WOS:000332191900004 Not found in local WOS DB
Título de la Revista: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volumen: 193
Editorial: ELSEVIER SCIENCE BV
Fecha de publicación: 2014
Página de inicio: 29
Página final: 37
DOI:

10.1016/j.resp.2014.01.005

Notas: ISI