Magnesium-doped zinc oxide nanoparticles alter biofilm formation of Proteus mirabilis

Iribarnegaray, Victoria; Navarro, Nicolas; Robino, Luciana; Zunino, Pablo; Morales, Javier; Scavone, Paola

Abstract

Aim: Proteus mirabilis biofilms colonize medical devices, and their role in microbial pathogenesis is well established. Magnesium-doped zinc oxide nanoparticles (ZnO:MgO NPs) have potential antimicrobial properties; thus, we aimed at evaluating the antibiofilm activity of ZnO:MgO NPs against P. mirabilis biofilm. Materials & methods: After synthesis and characterization of ZnO:MgO NPs and their addition to a polymer film, we evaluated the stages of P. mirabilis biofilm development over glass coverslip covered by different concentrations of ZnO:MgO NPs. Results: Low concentrations of ZnO:MgO NPs affect the development of P. mirabilis biofilm. Descriptors showed reduced values in bacterial number, bacterial volume and extracellular material. Conclusion: Our results highlight this new application of ZnO:MgO NPs as a potential antibiofilm strategy in medical devices.

Más información

Título según WOS: Magnesium-doped zinc oxide nanoparticles alter biofilm formation of Proteus mirabilis
Título según SCOPUS: Magnesium-doped zinc oxide nanoparticles alter biofilm formation of Proteus mirabilis
Título de la Revista: NANOMEDICINE
Volumen: 14
Número: 12
Editorial: Future Medicine Ltd.
Fecha de publicación: 2019
Página de inicio: 1551
Página final: 1564
Idioma: English
DOI:

10.2217/nnm-2018-0420

Notas: ISI, SCOPUS