Abstract

The receptor of advanced glycation end products (RAGE) is a multi‐ligand binding protein that was initially described as an AGEs‐binding protein. Other proteins, some of them classified as danger signals or alarmins have been described as RAGE ligands. Of note, RAGE shares some of its ligands with some member of the Toll‐like receptor family. Once RAGE is engaged by any of its ligands, the receptor is able to trigger robust pro‐inflammatory cellular responses. At present, RAGE has emerged as a relevant actor in the onset and development of chronic inflammation, which underlies many human diseases.