MODAL SHIFTS IN ACETYLCHOLINE-RECEPTOR CHANNEL GATING CONFER SUBUNIT-DEPENDENT DESENSITIZATION

NARANJO, D; BREHM, P

Abstract

During the transition from embryonic to adult skeletal muscle, a decreased mean channel open time and accelerated desensitization of nicotinic acetylcholine (ACh) receptors result from the substitution of an E subunit for gamma. A single ACh receptor channel of the embryonic type, expressed in Xenopus oocytes, interconverts between gating modes of short and long open time, whereas the adult receptor channel resides almost exclusively in the gating mode with short open time. Differences in the fraction of time spent in either gating mode account for the subunit dependence of both receptor open time and desensitization. Therefore, developmental changes in the kinetics of muscle ACh receptors may be imparted through subunit-dependent stabilization of intrinsic gating modes.

Más información

Título según WOS: ID WOS:A1993LH20500052 Not found in local WOS DB
Título de la Revista: SCIENCE
Volumen: 260
Número: 5115
Editorial: AMER ASSOC ADVANCEMENT SCIENCE
Fecha de publicación: 1993
Página de inicio: 1811
Página final: 1814
DOI:

10.1126/science.8511590

Notas: ISI