Accidental clozapine intoxication in a ten-year-old child

Borzutzky, A; Avello E.; Rumie, H.; PAris E

Abstract

Clozapine is a tricyclic dibenzodiazepine derivative used commonly in the treatment of schizophrenia. Severe side effects of overdose have been described in children. This report describes the unintentional ingestion of clozapine by a 10-y-o girl, presenting dramatic changes of mental status and progressive alteration of consciousness with a Glasgow Coma Scale drop from 12 to 7. Urine analysis revealed 500 ?g clozapine/L 24 h after ingestion. Full resolution of symptoms occurred after approximately 55 h with no sequels or alterations at follow-up. Awareness must be taken when administering atypical antipsychotics such as clozapine to children because of the severe intoxication effects cases reported.

Más información

Título según WOS: Accidental clozapine intoxication in a ten-year-old child
Título según SCOPUS: Accidental Clozapine Intoxication in a Ten-Year-Old Child
Título de la Revista: VETERINARY AND HUMAN TOXICOLOGY
Volumen: 45
Número: 6
Editorial: COMPARATIVE TOXICOLOGY LAB
Fecha de publicación: 2003
Página de inicio: 309
Página final: 310
Idioma: English
Notas: ISI, SCOPUS