Abstract

In Chile, prostate cancer is the sixth leading cause of cancer death in men. In this context, it is relevant to investigate potential therapeutic strategies to improve current treatment. Epithelial-to-mesenchymal transition is considered a critical feature of epithelial tumors, giving rise to a population of highly motile and invasive cancer cells. The Snail transcription factors have been directly involved in the role of inducing this transition. However, whether and how down-regulation or up-regulation of Snail1 influences colonogenesis of prostate cancer cells have not been clearly determined. In this present study, we discuss the role of Snail1 in the colonogenesis of prostate cancer, an essential property in the metastatic process. We also set forth to describe the morphology of cells with overexpression of Snail.