Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis

Cafferata, Emilio A.; Terraza?Aguirre, Claudia; Barrera, Romina; Faúndez, Nicolás; González, Nicolás; Rojas, Carolina; Melgar?Rodríguez, Samanta; Hernández, Marcela; Carvajal, Paola; Cortez, C.; González, Fermín E.; Covarrubias, Cristian; Vernal, R.

Abstract

Aim T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting alveolar bone resorption. Interleukin (IL)-35 is a novel anti-inflammatory cytokine with therapeutic properties in diseases whose pathogenesis is associated with the Th17/Treg imbalance; however, its role during periodontitis has not been established yet. This study aimed to elucidate whether IL-35 inhibits the alveolar bone resorption during periodontitis by modulating the Th17/Treg imbalance.

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Título según WOS: Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis
Título según SCOPUS: Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis
Título de la Revista: JOURNAL OF CLINICAL PERIODONTOLOGY
Volumen: 47
Número: 6
Editorial: Wiley
Fecha de publicación: 2020
Idioma: English
DOI:

10.1111/JCPE.13282

Notas: ISI, SCOPUS