Inflammatory markers IL-1 beta and RANK-L assessment after non-vital bleaching: A 3-month follow-up

Bersezio, Cristian; Sanchez, Francisca; Estay, Juan; Ledezma, Paulina; Vernal, Rolando; Garlet, Gustavo; Oliveira, Osmir Batista; Fernandez, Eduardo

Abstract

Objective This study assessed IL-1 beta and RANK-L levels in vivo and color stability of non-vital teeth bleached using hydrogen (35%) and carbamide (37%) peroxides 3 months after treatment. Materials and Methods Fifty teeth were randomly divided into two groups(n = 25):35% hydrogen peroxide (HP) or 37% carbamide peroxide (CP). Four sessions of intracoronal walking-bleach procedure were performed. IL-1 beta and RANK-L levels were assessed from gingival crevicular fluid samples (from three vestibular and three palatines sites) at eight different time-points: at the beginning of the study (baseline), after four sessions of intracanal bleaching, and at 1 week, 1 month, and 3 months posttreatment. The color variations were visually detected using Vita bleach shade guide (Delta SGU). Results Significant increases of IL-1 beta and RANK-L levels were detected at all time-points (all P < .05) when comparing each time-point to baseline, and a high correlation (>0.8-Spearman) between variables. According the Delta SGU values, a color change of five for HP and four for CP were detected. Conclusions Non-vital walking bleach technique promotes an increase in IL-1 beta and RANKL levels in periodontal tissues and also, it is maintained until the third-month posttreatment. Clinical Significance The internal whitening of teeth increases the levels of cytokines associated with inflammation and bone resorption 3 months after the whitening procedure is finished; this should warn of possible harmful effects of this whitening technique.

Más información

Título según WOS: Inflammatory markers IL-1 beta and RANK-L assessment after non-vital bleaching: A 3-month follow-up
Título según SCOPUS: Inflammatory markers IL-1? and RANK-L assessment after non-vital bleaching: A 3-month follow-up
Título de la Revista: JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
Volumen: 32
Número: 1
Editorial: Wiley
Fecha de publicación: 2020
Página de inicio: 119
Página final: 126
Idioma: English
DOI:

10.1111/jerd.12557

Notas: ISI, SCOPUS