Temperature-sensitive semi-IPN composite hydrogels for antibacterial applications

Jayaramudu, Tippabattini; Varaprasad, Kokkarachedu; Sadiku, Emmanuel Rotimi; Amalraj, John

Abstract

This investigation aims to develop bacterial-resistant temperature-sensitive semi-IPN silver composite hydrogels via a three-step method. Primarily, the temperature-sensitive semi-IPN hydrogels of N-isopropylacrylamide and various concentrations of Pluronic F-127 (PF 127), have been prepared via a free radical polymerization technique. Furthermore, silver ions were encapsulated in the temperature-sensitive semi-IPN hydrogels via the swelling process. Finally, the bacterial-resistant semi-IPN silver composite hydrogels were developed by using an aqueous neem extract as a reducing agent. Semi-IPN hydrogels with higher amount of PF-127 showed a water uptake that was three times better than the pristine poly (N-isopropylacrylamide). The phase transition temperature of the semi-IPN silver composite hydrogels was found to be 34.24 degrees C, which was confirmed from the swelling and the DSC studies. The resulting hydrogels were characterized by: FTIR, UV-vis, X-ray diffraction, SEM and TEM analyses. The TEM results confirmed the fact that the nanoparticles formed were of spherical shape with a dimension of (similar to)8 +/- 2 nm. The semi-IPN silver-composite hydrogels showed excellent bacteria inhibition against gram-positive bacteria. The results demonstrated that the temperature-sensitive semi-IPN silver-composite hydrogels developed can be employed for clinical applications.

Más información

Título según WOS: Temperature-sensitive semi-IPN composite hydrogels for antibacterial applications
Título según SCOPUS: Temperature-sensitive semi-IPN composite hydrogels for antibacterial applications
Título de la Revista: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volumen: 572
Editorial: Elsevier
Fecha de publicación: 2019
Página de inicio: 307
Página final: 316
Idioma: English
DOI:

10.1016/j.colsurfa.2019.04.012

Notas: ISI, SCOPUS