Abstract

Cardiovascular risk (CR) is associated with obstructive sleep apnea hypopnea syndrome (OSAHS). This association enhances the risk of major adverse cardiovascular events (MACE); nevertheless, data from hospitalized populations and interactions among these conditions remain unclear. Purpose: To evaluate the risk of MACE in the population with risk of OSAHS using the STOP-BANG questionnaire. Methods: We performed a prospective study in an academic hospital from 2017 to 2018. Data included demography, admissions, STOP-BANG score and CR using AHA scores. The primary outcome was risk of MACE in participants with low risk of OSAHS (STOP-BANG 0-2 points), risk of OSAHS (>= 3 points) and risk of moderate/severe OSAHS (>= 5 points). Risk of MACE was evaluated using odds ratios (OR), and average CR was evaluated using the t-test. Results: A total of 441 participants were included. The cumulative prevalence of STOP BANG >= 3 points was 80.9%, and that of >= 5 points was 41.6%. OR of MACE >= 3 points was 3.93 (CI 2.08-7.24) (p < 0.001) compared with < 3 points, and Average CR was 10.91% (SD +/- 2.13) at < 3 points versus 24.3% (SD +/- 1.24) for (>= 3 points) for (>= 5 points) OR of MACE was 1.72 (CI 1.18-2.59) (p = 0.005) and average CR was 26.14% (SD +/- 1.63). However, after multivariable analysis, gender differences and previous heart failure were independently associated to MACE. Conclusion: The risk of OSAHS in the hospitalized population is high. This population has a higher risk of MACE and higher CRs than do low-risk participants. Conversely, gender and heart failure are potential cofounders. (C) 2019 Elsevier B.V. All rights reserved.