Targeting hsp90 family members: A strategy to improve cancer cell death

Buc Calderon P.; Beck R.; Glorieux C.

Abstract

A crucial process in biology is the conversion of the genetic information into functional proteins that carry out the genetic program. However, a supplementary step is required to obtain functional proteins: the folding of the newly translated polypeptides into well-defined, three-dimensional conformations. Proteins chaperones are crucial for this final step in the readout of genetic information, which results in the formation of functional proteins. In this review, a special attention will be given to the strategies targeting hsp90 family members in order to increase cancer cell death. We argue that disruption of hsp90 machinery and the further client protein degradation is the main consequence of hsp90 oxidative cleavage taking place at the N-terminal nucleotide-binding site. Moreover, modulation of Grp94 expression will be discussed as a potential therapeutic goal looking for a decrease in cancer relapses.

Más información

Título según WOS: Targeting hsp90 family members: A strategy to improve cancer cell death
Título según SCOPUS: Targeting hsp90 family members: A strategy to improve cancer cell death
Título de la Revista: BIOCHEMICAL PHARMACOLOGY
Volumen: 164
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2019
Página de inicio: 177
Página final: 187
Idioma: English
DOI:

10.1016/j.bcp.2019.04.010

Notas: ISI, SCOPUS