Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities

Wyneken, U; Marengo, JJ; Villanueva, S.; Soto, D; Sandoval, R; Gundelfinger ED; Orrego F.

Abstract

Purpose: To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid. Methods: We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue. Results: Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-D-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs. Conclusions: These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.

Más información

Título según WOS: Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities
Título según SCOPUS: Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities
Título de la Revista: EPILEPSIA
Volumen: 44
Número: 2
Editorial: Wiley
Fecha de publicación: 2003
Página de inicio: 243
Página final: 246
Idioma: English
URL: http://doi.wiley.com/10.1046/j.1528-1157.2003.17602.x
DOI:

10.1046/j.1528-1157.2003.17602.x

Notas: ISI, SCOPUS