BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design

Covián C.; Fernández-Fierro A.; Retamal-Díaz A.; Díaz F.E.; Vasquez A.E.; Lay M.K.; Riedel, C. A.; González P.A.; Bueno, S. M.; Kalergis A.M.

Abstract

The Bacillus Calmette-Guerin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with BCG reduces mortality in newborns and induces an improved innate immune response against microorganisms other than Mycobacterium tuberculosis, such as Candida albicans and Staphylococcus aureus. Innate immune cells, including monocytes and natural killer (NK) cells, contribute to this non-specific immune protection in a way that is independent of memory T or B cells. This phenomenon associated with a memory-like response in innate immune cells is known as "trained immunity." Epigenetic reprogramming through histone modification in the regulatory elements of particular genes has been reported as one of the mechanisms associated with the induction of trained immunity in both, humans and mice. Indeed, it has been shown that BCG vaccination induces changes in the methylation pattern of histones associated with specific genes in circulating monocytes leading to a "trained" state. Importantly, these modifications can lead to the expression and/or repression of genes that are related to increased protection against secondary infections after vaccination, with improved pathogen recognition and faster inflammatory responses. In this review, we discuss BCG-induced cross-protection and acquisition of trained immunity and potential heterologous effects of recombinant BCG vaccines.

Más información

Título según WOS: BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design
Título según SCOPUS: BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design
Título de la Revista: FRONTIERS IN IMMUNOLOGY
Volumen: 10
Editorial: FRONTIERS MEDIA SA
Fecha de publicación: 2019
Idioma: English
DOI:

10.3389/fimmu.2019.02806

Notas: ISI, SCOPUS