Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)-infected Chilean patients

Palomo I.; Alarcon M.; Sepulveda, C; Pereira J.; Espinola, R; Pierangeli, S

Abstract

Antiphospholipid (aPL) and antiplatelet (aPlt) antibodies, found in patients with autoimmune diseases, are also detected in infectious diseases. The purpose of this study was to examine the prevalence of these antibodies in HIV patients and to evaluate an association of these antibodies with thrombocytopenia and/or thrombosis. Sixty-three HIV-seropositive patients and 52 normal controls were studied. Anticardiolipin (aCL), anti-?2 glycoprotein I (anti-?2GPI), and antiprothrombin (aPT) antibodies were determined and the lupus anticoagulant (LA) test was performed. Antiplatelet antibodies (aPT) were also determined. Seven out of 63 (12.7%) HIV patients were positive for aCL, four of 63 (6.3%) for anti-? 2GPI, and five of 63 (7.9%) for aPT. No patients studied were LA positive. Six out of 63 (9.5%) patients were positive for aPlt. One of them showed weak reactivity for GPIb-IX. The platelet count of patients (202 ± 63 × 103 platelets/?L) was significantly lower than in the controls (343 ± 6 × 103 platelets/?L) (P<0.001). There was no correlation between the presence of aPL and/or aPlt and thrombocytopenia. Of the HIV-infected patients, 22.2% presented aPL and 9.4% aPlt antibodies. In this study, the presence of aPL and aPlt antibodies was not associated with the development of thrombosis and/or thrombocytopenia. © 2003 Wiley-Liss, Inc.

Más información

Título según WOS: Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)-infected Chilean patients
Título según SCOPUS: Prevalence of Antiphospholipid and Antiplatelet Antibodies in Human Immunodeficiency Virus (HIV)-Infected Chilean Patients
Título de la Revista: JOURNAL OF CLINICAL LABORATORY ANALYSIS
Volumen: 17
Número: 6
Editorial: Wiley
Fecha de publicación: 2003
Página de inicio: 209
Página final: 215
Idioma: English
URL: http://doi.wiley.com/10.1002/jcla.10093
DOI:

10.1002/jcla.10093

Notas: ISI, SCOPUS