Abstract

Matrices composed of blends of alginate/whey and iron sources as ferrous sulfate (FS) and bovine spray-dried blood cells (BC) were prepared by ionic gelation, characterized, and tested in vitro as a carrier for the oral delivery of iron. The major components of these matrices were carbohydrates and proteins, and their iron concentrations ranged from 3 to 34 mg per matrix. By using scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction and differential scanning calorimetry, these matrices were deemed stable and we observed that iron was successfully incorporated into them. In terms of resistance, we observed that it decreased along with the increasing concentration of FS for each of the matrix formulations. Our results indicate that these matrices released low concentrations of iron under gastric conditions simulated in vitro (2.4-11.1%), whereas iron was released massively under intestinal conditions (83-100%). We also observed that matrices were gradually degraded under intestinal conditions. Consequently, our results indicate that these matrices could be used as a viable strategy for oral iron supplementation.