HIF-hypoxia signaling in skeletal muscle physiology and fibrosis

Valle-Tenney R.; Rebolledo D.; Acuña M.J.; Brandan E.

Abstract

Hypoxia refers to the decrease in oxygen tension in the tissues, and the central effector of the hypoxic response is the transcription factor Hypoxia-Inducible Factor alpha (HIF1-alpha). Transient hypoxia in acute events, such as exercising or regeneration after damage, play an important role in skeletal muscle physiology and homeostasis. However, sustained activation of hypoxic signaling is a feature of skeletal muscle injury and disease, which can be a consequence of chronic damage but can also increase the severity of the pathology and worsen its outcome. Here, we review evidence that supports the idea that hypoxia and HIF-1 alpha can contribute to the establishment of fibrosis in skeletal muscle through its crosstalk with other profibrotic factors, such as Transforming growth factor beta (TGF-beta), the induction of profibrotic cytokines expression, as is the case of Connective Tissue Growth Factor (CTGF/CCN2), or being the target of the Renin-angiotensin system (RAS).

Más información

Título según WOS: HIF-hypoxia signaling in skeletal muscle physiology and fibrosis
Título según SCOPUS: HIF-hypoxia signaling in skeletal muscle physiology and fibrosis
Título de la Revista: Journal of Cell Communication and Signaling
Volumen: 14
Número: 2
Editorial: Springer
Fecha de publicación: 2020
Idioma: English
DOI:

10.1007/S12079-020-00553-8

Notas: ISI, SCOPUS