Coryneform Bacteria in Granulomatous Lobular Mastitis: Morphological Diagnosis in Breast Biopsies

Oddo, D; Stefanelli, A; Villarroel, A; Mendez, GP

Keywords: Granulomatous lobular mastitis, coryneform lipophilic bacteria, pathological diagnosis, Gram and Grocott stains, breast inflammation

Abstract

Granulomatous lobular mastitis is a rare disease whose origin is still unknown and shows an increase in its frequency. Morphological, microbiological, and molecular biology studies have linked this disease to lipophilic and fastidious corynebacteria, suggesting its possible infectious etiology. This series describes and reviews in detail the distinctive morphological characteristics of the bacteria present in the granulomas of this disease, the usefulness of histochemical techniques for their identification, and our proposal for a tissue quantification score for the bacteria. The MacCallum-Goodpasture method of Gram's stain turned out to be the gold standard for examination, but we also highlight the efficiency of hematoxylin and eosin stain when it is exhaustively examined as well as the Grocott stain to evaluate the bacterial pleomorphism method, which is often underutilized.

Más información

Título según WOS: Coryneform Bacteria in Granulomatous Lobular Mastitis: Morphological Diagnosis in Breast Biopsies
Título de la Revista: INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
Volumen: 27
Número: 4
Editorial: SAGE PUBLICATIONS INC
Fecha de publicación: 2019
Página de inicio: 380
Página final: 386
Idioma: English
DOI:

10.1177/1066896918815580

Notas: ISI