Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor

Salgado, F; Caballero, J; Vargas, R; Cornejo, A; Areche, C

Keywords: alzheimer's disease, lichens, tau protein

Abstract

Alzheimer's disease (AD) is the most common form of dementia involving A beta and tau protein. So far, AD cure remains elusive, but considering that AD progresses throughout tau pathology, which turns tau protein an appropriate target, besides tau is also included in other neurodegenerative disorders named as tauopathies. Here, we have isolated seventeen compounds belonging to six lichens species. Due to scarce of spectroscopic data of the compound 5,7-dihydroxy-6-methylphthalide, we explained their structural elucidation based on NMR data. In this study, we show that only tenuiorin from Umbilicaria antarctica inhibited 50% of tau 4R at 100 mu M. Then, we shown that molecular interactions of tenuiorin with the steric zipper model of the hexapeptide (306)VQIVYK(311) were studied by docking calculations and the results suggested that tenuiorin forms both hydrogen bonds with lysine and glutamine side chains and forms several hydrophobic interactions with valine and lysine from (306)VQIVYK(311) motif. [GRAPHICS] .

Más información

Título según WOS: Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor
Título de la Revista: NATURAL PRODUCT RESEARCH
Volumen: 34
Número: 5
Editorial: TAYLOR & FRANCIS LTD
Fecha de publicación: 2020
Página de inicio: 646
Página final: 650
Idioma: English
DOI:

10.1080/14786419.2018.1492576

Notas: ISI