Abstract

New podands derived from 4-hydroxy-1H-pyrazole have been prepared. Their complexing properties towards cations (Na+, K+, NH4+) and some neurotransmitters (dopamine and norepinephrine) have been studied, using biphasic extraction experiments, molecular modelling, and a NMR titration. Podand 10, 1-benzyl-4-hydroxy-3,5-bis(2, 5, 8, 11-tetraoxadodecan-l-yl)-1H-pyrazole, showed an interesting selective complexation of dopamine. (C) 1999 Elsevier Science Ltd. All rights reserved.