Article ISI
BIOORGANIC MEDICINAL CHEMISTRY LETTERS  (1998)

Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds

Segarra, V; Crespo, MI; Pujol, F; Beleta, J; Domenech, T; Miralpeix, M; Palacios, JM; Castro, A; Martinez, A

Abstract

A 4-centre PDE 4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developping PDE 4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured. (C) 1998 Elsevier Science Ltd. All rights reserved.

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Título según WOS: ID WOS:000072466300021 Not found in local WOS DB
Título de la Revista: BIOORGANIC MEDICINAL CHEMISTRY LETTERS
Volumen: 8
Número: 5
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 1998
Página de inicio: 505
Página final: 510
DOI:

10.1016/S0960-894X(98)00058-4
Notas: ISI