Article ISI
BIOORGANIC MEDICINAL CHEMISTRY LETTERS  (1992)

(E)-1-ALKYL-[2-(1H-AZOL-2-YL)VINYL]PYRIDINIUM SALTS - THEORETICAL-ANALYSIS, SYNTHESIS AND EVALUATION OF THEIR INTERACTION WITH CHOLINE-ACETYLTRANSFERASE

ALCALDE, E; ROCA, T; BARAT, A; RAMIREZ, G; GOYA, P; MARTINEZ, A

Abstract

A new type of aza-analogues of (E)-4-[2-(1-naphthylvinyl)]-1-substituted pyridinium salts (NVP+) has been designed in order to study their in vitro inhibitory activity towards ChAT. A theoretical analysis has been performed and several examples of (E)-1-alkylazolylvinylpyridinium salts have been synthesized. Among them, the indolylvinylpyridinium salt is the only one showing some ChAT inhibition.

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Título según WOS: ID WOS:A1992KD88900006 Not found in local WOS DB
Título de la Revista: BIOORGANIC MEDICINAL CHEMISTRY LETTERS
Volumen: 2
Número: 12
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 1992
Página de inicio: 1493
Página final: 1496
DOI:

10.1016/S0960-894X(00)80415-1
Notas: ISI