Intramolecular cyclization: a promising strategy in the prodrug conception

Santos, Cledir

Abstract

Many drugs used for the treatment of common diseases are associated with various adverse effects and limited bioavailability. The suppression of such problems continues to be a very important target for scientists. The development of prodrugs for controlled release in vivo is an attractive way to overcome these problems. Classical in prodrug is an inactive molecule which the parent drug is covalently bonded to a carrier unit, and which can liberate the drug through chemical or enzymatic pathways. A new and interesting prodrug system for alcohol, and thiol drugs takes advantage of several easy intramolecular cylization reactions. So, the cyclization process can control the release rate of the parent drug. In this paper is a review, about the prodrug strategies based on intramolecular cyclization reactions is presented.

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Título según WOS: ID WOS:000261701700004 Not found in local WOS DB
Título de la Revista: REVISTA BRASILEIRA DE CIENCIAS FARMACEUTICAS
Volumen: 44
Número: 3
Editorial: UNIV SAO PAULO, CONJUNTO QUIMICAS
Fecha de publicación: 2008
Página de inicio: 349
Página final: 360
Notas: ISI