Abstract

Overweight and obesity are associated with chronic and subclinical inflammation due to an imbalance of inflammatory mediators. However, the association with gene polymorphism has been rarely studied in children. The aim of this study was to determine if serum concentrations of C-reactive protein (CRP) and interleukin-6 (IL-6) are related to the IL6 rs1800795, 1L6 rs2069845 and CRP rs1205 polymorphisms (SNPs) according to body mass index (BMI) in a sample of children and adolescents. A cross-sectional study in 470 students between 7 and 17 years of age of anthropometric characteristics, high sensitivity-CRP (Hs-CRP) and IL-6 levels and three SNPs genotyped. The prevalence ratio of hs-CRP >3 mg/L in obese individuals was 4.15 (CI 2.43-7.06; p = 0.01), and it was 1.91 (CI 1.03-3.55; p = 0.03) in overweight individuals and 1.74 (CI 1.05-2.88 p = 0.03) in females. Individuals with waist circumference (WC) and body fat percentage (BF%) alterations showed elevated levels of hs-CRtric measurement increases CRP levels, especially combinations with obesity body mass index (EMI): BMI + WC and BMI + BF%. Among the overweight/obesity group, T allele carriP (p = 4.3 x 10(-5) and p = 5.3 x 10(-6)). The combination of any two anthropomeers of CRP rsl 205 showed lower levels of hs-CRP (0.5, IQR = 0.3-1.8 mg/L) than CC homozygotes (1.5, IQR = 0.4-3.4 mg/L, p = 0.018). Additionally, considering subjects with two or three anthropometric alterations for CRP rs1205: rs1205 T allele carriers had lower levels of hs-CRP (0.7, IQR = 0.3-2.7 mg/L) than CC homozygotes (1.2, IQR = 0.5-3.5 mg/L, p = 0.02). In conclusion, carriers of the rsl 205/T allele with higher BMIs had lower levels of hs-CRP. Schoolchildren who were overweight/obese had higher levels of CRP and IL-6, whereas individuals with WC and BF% alterations had higher levels of CRP. (C) 2016 Elsevier Ltd. All rights reserved.