Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease, the most common cause of dementia in senile population. According to the World Health Organization, AD represents around 12% of people over 65 worldwide. There are about 48 million people suffering from AD and, it is estimates that by 2050 the amount will increase to about 91 million. Due to its etiological agents, neurofibrillary tangles (NFT) and amyloid plaques (AP), several attempts to explain the genesis and progression of AD have been proposed. Pathological variants of tau protein, are the main precursors for AD onset, with a molecular mechanism based on neuroinflammatory processes, as explained in the context of the neuroimmunomodulation theory.