Merkel Cell Polyomavirus Detected in Head and Neck Carcinomas From Chile

Muñoz, Juan P.; Blanco, Rancés; Osorio, Julio C.; Oliva, Carolina; Diaz, Maria J.; Carrillo-Beltran, D; Aguayo, Rebeca; Castillo, Andrés; Tapia, Julio C.; Calaf, Gloria M; Gaggero, Aldo; Aguayo, Francisco

Keywords: Cancer, head and neck, polyomavirus

Abstract

Background: The role of human polyomaviruses (HPyVs) in epithelial tumors such as head and neck carcinomas (HNSCCs) including oral and oropharyngeal carcinomas has not been established. In this study, we evaluated for the first time the presence of Merkel cell polyomavirus (MCPyV), BK human polyomavirus (BKPyV), and JC human polyomavirus (JCPyV) in HNSCCs from Chilean subjects. Methods: One hundred and twenty HNSCCs were analyzed for the presence of MCPyV, BKPyV and JCPyV using real-time polymerase chain reaction procedures. In addition, 54 oral brushes from age- and sex-paired subjects were analyzed. Results: Of the total of 120 HNSCCs, 15 were positive for MCPyV (12.5%). Only one case was positive for BKPyV (0.8%) and none for JCPyV (0%). In subjects without cancer, only one case (1.8%) resulted positive for MCPyV and none for JCPyV and BKPyV. MCPyV was associated with HNSCCs (p = 0.0239; OR = 7.571; 95% CI: 1.192–81.46). No association was found between age (p = 0.1996), gender (p = 0.7111) or differentiation status (p > 0.9999) and MCPyV presence in HNSCCs. Conclusions: MCPyVs were detected in HNSCCs from Chilean patients and were not detected in oral brushes from patients without cancer. More studies are warranted for defining an etiological role and clinical/molecular consequences of these viruses in HNSCCs.

Más información

Título de la Revista: INFECTIOUS AGENTS AND CANCER
Volumen: 15
Número: 4
Editorial: BMC
Fecha de publicación: 2020
Página de inicio: 1
Página final: 5
Idioma: English
Financiamiento/Sponsor: Fondecyt
DOI:

doi: 10.1186/s13027-020-0276-z

Notas: AUTOR DE CORRESPONDENCIA; ISI/WOS