Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products

Naghiyev, Farid N.; Cisterna, Jonathan; Khalilov, Ali N.; Maharramov, Abel M.; Askerov, Rizvan K.; Asadov, Khammed A.; Mamedov, Ibrahim G.; Salmanli, Khaver S.; Cardenas, Alejandro; Brito, Ivan

Abstract

We report an unprecedented multicomponent reaction of acetoacetanilide with malononitrile leading to a structurally novel bicyclic product (9) in a high yield. The structure has been confirmed by X-ray crystallography and comparative Hirshfeld surface analysis of 5-cyano-2-hydroxy-2-methyl-N-phenyl-4-(yridine-4-yl)-6-(thiophen-2-yl)-3,4-dihydro-2H-pyran-3-carboxamide 2, 5-cyano-2-hydroxy-2-methyl-6-oxo-N-phenyl-4-(thiophen-2-yl)piperidine-3-carboxamide 4 and 2-(8-amino-7,8a-dicyano-1-imino-4a-methyl-3-oxo-2-phenyl-1,3,4,4a,5,8a-hexahydroisoquinolin-6(2H)-ylidene)-N-phenylacetamide 9.

Más información

Título según WOS: Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products
Título de la Revista: MOLECULES
Volumen: 25
Número: 9
Editorial: MDPI
Fecha de publicación: 2020
DOI:

10.3390/MOLECULES25092235

Notas: ISI