Patent
 

A single-dose and extended-release injectable pharmaceutical composition comprising polymer-nanoparticles composed of polyethylene glycol-bonded poly-ethylene glycol (MPEG-PLLA), loaded with drugs which inhibit the panexin-1 channel, including carbenoxolone, probenicid 10 panx, or a Combination thereof, useful for treating or preventing chronic pain, in animals or humans

Constandil, Luis; Bravo, David; Retamales, Jeffri; Ramírez, Paulina; Vilos O, Cristian; Pelissier, Teresa