Effect of excessive gestational weight on daughters' breast density at the end of puberty onset

Lopez, Ana; Luisa Garmendia, Maria; Shepherd, John; Michels, Karin; Corvalan, Camila; Pereira, Ana

Abstract

The effect of excessive gestational weight gain (EGWG) is related to adverse health outcomes in the offspring; however, its effect on the daughters' breast density is unclear. We aimed to assess the association between EGWG and daughters' breast composition (% of fibroglandular volume (%FGV) and absolute fibroglandular volume (AFGV)) at Tanner stage 4 (Tanner B4)). We included 341 girls and their mothers from an ongoing cohort of low-income Chilean girls born from 2002-2003. Maternal gestational weight gain was self-reported in 2007, and breast density by digital mammography was measured in 2010. Weight, height and breast composition by dual X-ray absorptiometry (DXA) were measured in daughters at Tanner B4. Logistic regression models were run to assess the association between EGWG and the 80th percentile of %FGV and AFGV. Mean gestational weight gain was 13.7kg (SD=6.9kg). Women with pregestational overweight or obesity exceeded the recommended gestational weight gain (58.8% vs. 31.8%, respectively). Daughters of women who had EGWG had higher levels of AFGV (OR: 2.02; 95%CI 1.16-3.53) at Tanner B4, which could be explained by metabolic and hormonal exposure in utero. However, we did not observe an association with %FGV.

Más información

Título según WOS: Effect of excessive gestational weight on daughters' breast density at the end of puberty onset
Título de la Revista: SCIENTIFIC REPORTS
Volumen: 10
Número: 1
Editorial: NATURE PORTFOLIO
Fecha de publicación: 2020
DOI:

10.1038/S41598-020-63260-9

Notas: ISI