Article ISI
CHEMICAL COMMUNICATIONS  (2019)

Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

Carbajo-Gordillo, Ana I.; Rodriguez-Lavado, Julio; Jimenez Blanco, Jose Luis; Benito, Juan M.; Di Giorgio, Christophe; Velaz, Itziar; Tros de Ilarduya, Concepcion; Ortiz Mellet, Carmen; Garcia Fernandez, Jose M.

Abstract

An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared fromthe disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery in vitro and in vivo.

Más información

Título según WOS: ID WOS:000475674300032 Not found in local WOS DB
Título de la Revista: CHEMICAL COMMUNICATIONS
Volumen: 55
Número: 57
Editorial: ROYAL SOC CHEMISTRY
Fecha de publicación: 2019
Página de inicio: 8227
Página final: 8230
DOI:

10.1039/c9cc04489b
Notas: ISI