History of bystander effects research 1905-present; what is in a name?

Mothersill, Carmel; Rusin, Andrej; Fernandez-Palomo, Cristian; Seymour, Colin

Abstract

Purpose: This review, which arose from a Radiation Research Society History symposium, traces the history of 'bystander effects' or 'indirect effects'(also known as 'abscopal effects', 'clastogenic effects' and more recently 'the secretosome'). In 1905, Murphy first drew attention to effects caused by the injection of irradiated cells into animals. In the present day, bystander effects are seen as part of the secretosome, where they coordinate responses to stressors at the tissue, organism, and population level. The review considers the history and also the reasons why this process of information exchange/communication appears to have been discovered and forgotten several times. The review then considers the evolution of our understanding of the mechanisms and what relevance these effects may have in radiation protection and radiotherapy. Conclusions: The authors conclude that the phenomenon currently described as a 'bystander effect' has been described under a variety of different names since 1905. However recent advances in biology have made it possible to investigate mechanisms and potential impacts more fully. This has led to the current upsurge in research into this effect of radiation.

Más información

Título según WOS: ID WOS:000442625400002 Not found in local WOS DB
Título de la Revista: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Volumen: 94
Número: 8
Editorial: Taylor and Francis Ltd.
Fecha de publicación: 2018
Página de inicio: 696
Página final: 707
DOI:

10.1080/09553002.2017.1398436

Notas: ISI