Experimental design and reporting standards for improving the internal validity of pre-clinical studies in the field of pain: Consensus of the IMI-Europain consortium

Knopp, KL; Stenfors, C; Baastrup, C; Bannon, AW; Calvo, M; Caspani, O; Currie, G; Finnerup, N; Huang, W; Kennedy, JD; Lefevre, I; Machin, I; Macleod, M; Rees, H; Rice, ASC; et. al.

Abstract

Pain is a subjective experience, and as such, pre-clinical models of human pain are highly simplified representations of clinical features. These models are nevertheless critical for the delivery of novel analgesics for human pain, providing pharmacodynamic measurements of activity and, where possible, on-target confirmation of that activity. It has, however, been suggested that at least 50% of all pre-clinical data, independent of discipline, cannot be replicated. Additionally, the paucity of “negative” data in the public domain indicates a publication bias, and significantly impacts the interpretation of failed attempts to replicate published findings. Evidence suggests that systematic biases in experimental design and conduct and insufficiencies in reporting play significant roles in poor reproducibility across pre-clinical studies. It then follows that recommendations on how to improve these factors are warranted.

Más información

Título de la Revista: SCANDINAVIAN JOURNAL OF PAIN
Volumen: 7
Editorial: Elsevier BV
Fecha de publicación: 2015
Página de inicio: 58
Página final: 70
Idioma: English
Financiamiento/Sponsor: IMI-Europain
Notas: ISI