Chapter 17 - When the Good Turns Bad: Challenges in the Targeting of Autophagy in Neurodegenerative Diseases

Nassif, Melissa; Medinas, Danilo; Castillo, Karen; Gherardelli C.; Hetz, Claudio; M.A. Hayat

Keywords: therapy, neurodegeneration, autophagy, protein misfolding

Abstract

Autophagy is becoming an attractive target to treat neurodegenerative diseases involving protein misfolding and abnormal aggregation. However, the mechanisms underlying the precise role of autophagy in the pathology are still unclear. Accumulating evidence indicates that autophagy impairment may actually contribute to the neurodegeneration process. In this chapter, we discuss several examples indicating the therapeutic effects of manipulating (enhancing) autophagy in preclinical models of neurodegeneration, in addition to identifying key molecular alterations in the autophagy pathway at different levels in these diseases. Challenges in the future development of therapeutic strategies to target the autophagy pathway are discussed.

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Editorial: ELSEVIER ACADEMIC PRESS INC
Fecha de publicación: 2015
Página de inicio: 259
Página final: 272
Idioma: English
URL: https://www.sciencedirect.com/science/article/pii/B9780128010334000175
DOI:

https://doi.org/10.1016/B978-0-12-801033-4.00017-5