The mammalian acrosome as a secretory lysosome: New and old evidence

Moreno, RD; Alvarado CP

Abstract

The morphological and biochemical characteristics of the acrosome depart well from any other vesicles in somatic cells, making it one of a kind amongst secretory vesicles. The components of the acrosome include a mixture of unique enzymes like acrosin and other enzymes that when present in somatic cells are commonly found in lysosomes, peroxisomes, and even in the cytoplasm. Several observations have pointed out that acrosomal biogenesis has unique features not previously described in secretory vesicle biogenesis of somatic cells. In this review we discuss the evidence supporting a molecular link between the machinery involved in lysosome and acrosome biogenesis, link which may help account for the acrosome unique composition. © 2006 Wiley-Liss, Inc.

Más información

Título según WOS: The mammalian acrosome as a secretory lysosome: New and old evidence
Título según SCOPUS: The mammalian acrosome as a secretory lysosome: New and old evidence
Título de la Revista: MOLECULAR REPRODUCTION AND DEVELOPMENT
Volumen: 73
Número: 11
Editorial: Wiley
Fecha de publicación: 2006
Página de inicio: 1430
Página final: 1434
Idioma: English
URL: http://doi.wiley.com/10.1002/mrd.20581
DOI:

10.1002/mrd.20581

Notas: ISI, SCOPUS