Getting intimate: Lysosomes and ER rendezvous to control autophagy

Pihán, Philippe; Hetz, Claudio

Abstract

The endoplasmic reticulum (ER) is the source of lysosomal calcium. The finding that the protein TMBIM6 –a putative ER calcium channel and cell death regulator –promotes calcium transfer from the ER to lysosomes to induce autophagy uncovers a missing piece in the puzzle of inter-organelle communication.

Más información

Título de la Revista: Cell Calcium
Volumen: 91
Fecha de publicación: 2020
Página de inicio: 102249
DOI:

10.1016/j.ceca.2020.102249