Complete genome sequence of Central Africa human T-cell lymphotropic virus subtype 1b

Zanella, Louise; Otsuki, Koko; Michel Abanto Marin; Bendet, Izidro; Vicente, Ana Carolina Paulo

Keywords: HTLV-1b, Genome, Central Africa

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) has a global spread, and it is estimated that around 20 million persons are infected. Seven major genetic subtypes are recognized. However, there are complete genomes only from the HTLV-1a (cosmopolitan) and HTLV-1c (Melanesian) subtypes. Here, the first full-length genome of an HTLV-1b strain, a subtype so far restricted to Central African countries, is revealed. The genome size of HTLV-1b SF26, a strain isolated in Brazil, was determined to be 8,267 bp. The genomic analysis showed that all characteristic regions and genes of a prototypic HTLV-1 virus are conserved. This genome can provide information for further studies on the evolutionary history and pathogenic potential of this human oncovirus.

Más información

Título de la Revista: JOURNAL OF VIROLOGY
Volumen: 86
Editorial: AMER SOC MICROBIOLOGY
Fecha de publicación: 2012
Página de inicio: 12451
Página final: 12451
Idioma: Ingles
URL: https://europepmc.org/article/med/23087114