N-Acetyl Cysteine and Catechin-Derived Polyphenols: A Path Toward Multi-Target Compounds Against Alzheimer's Disease

Andrade, Victor; Cortes, Nicole; Pastor, Gabriela; Gonzalez, Andrea; Ramos-Escobar, Nicolas; Pastene, Edgar; Rojo, Leonel E; Maccionia, Ricardo B.

Abstract

Background: Alzheimer's disease (AD) is a multifactorial disease, that involves neuroinflammatory processes in which microglial cells respond to "damage signals". The latter includes oligomeric tau, iron, oxidative free radicals, and other molecules that promotes neuroinflammation in the brain, promoting neuronal death and cognitive impairment. Since AD is the first cause of dementia in the elderly, and its pharmacotherapy has limited efficacy, novel treatments are critical to improve the quality of life of AD patients. Multitarget therapy based on nutraceuticals has been proposed as a promising intervention based on evidence from clinical trials. Several studies have shown that epicatechin-derived polyphenols from tea improve cognitive performance; also, the polyphenol molecule N-acetylcysteine (NAC) promotes neuroprotection.

Más información

Título según WOS: N-Acetyl Cysteine and Catechin-Derived Polyphenols: A Path Toward Multi-Target Compounds Against Alzheimer's Disease
Título de la Revista: JOURNAL OF ALZHEIMERS DISEASE
Volumen: 75
Número: 4
Editorial: IOS Press
Fecha de publicación: 2020
Página de inicio: 1219
Página final: 1227
DOI:

10.3233/JAD-200067

Notas: ISI