Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae)

Lianza, Mariacaterina; Verdan, Maria Helena; de Andrade, Jean Paulo; Poli, Ferruccio; de Almeida, Larissa; Costa-Lotufo, Leticia, V; Cunha Neto, Alvaro; Oliveira, Sarah C. C.; Bastida, Jaume; Batista, Andrea N. L.; Batista, Joao M., Jr.; Borges, Warley S.

Abstract

The phytochemical study of Hippeastrum goianum led to the identification of 13 compounds by means of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Compounds 7-demethoxy-9-O-methylhostasine (1) and 7-deoxi-trans-dihydronarciclasine (2) had their absolute configurations determined by vibrational circular dichroism (VCD). This is the first time that compound 1 is described in the Amaryllidaceae family. The cytotoxicity of all isolated compounds was tested against colorectal carcinoma (HCT 116), breast carcinoma (MCF-7), and non-tumor human retinal pigment epithelium (RPE) cell lines. The half-maximum inhibitory concentration (IC50) of compound 2 against each cell line was equivalent to the positive control (doxorubicin), indicating a considerable cytotoxic activity.

Más información

Título según WOS: ID WOS:000577634100019 Not found in local WOS DB
Título de la Revista: JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Volumen: 31
Número: 10
Editorial: SOC BRASILEIRA QUIMICA
Fecha de publicación: 2020
Página de inicio: 2135
Página final: 2145
DOI:

10.21577/0103-5053.20200116

Notas: ISI