Portal del Investigador
Over-activation of Panx1 in neurons leads to intracellular Ca2+ overload and subsequent defects in neuronal cytoskeleton and signaling receptor trafficking supporting synaptic defects in an Alzheimer´s disease model
Más información
| Fecha de publicación: | 2020 |
| Objetivos: | 1: To evaluate the contribution of Panx1 channels to the neuronal intracellular Ca2+ 2: To evaluate the implication of Panx1 activity in the Ca2+-dependent synaptotoxic signaling in AD 3: To evaluate whether the neuronal cytoskeleton is a downstream target in the Panx1-mediated synaptotoxic signal |
| Instrumento: | FONDECYT |
| Año de Inicio/Término: | 2020-2024 |
| Financiamiento/Sponsor: | CONICYT |
| Rol del Usuario: | INVESTIGADOR(A) RESPONSABLE |
| DOI: |
1201342 |